Santa Cruz Real Estate Blog

Engineered ‘mini’ CRISPR Genome Editing System Developed

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it's time to reimagine CRISPR as a Swiss Army knife.

Crispr, Genetic, Scissors, Dna, Biology, Science"CRISPR can be as simple as a cutter, or more advanced as a regulator, an editor, a labeler or imager. Many applications are emerging from this exciting field," said Qi, who is also an assistant professor of chemical and systems biology in the Stanford School of Medicine and a Stanford ChEM-H institute scholar.

The many different CRISPR systems in use or being clinically tested for gene therapy of diseases in the eye, liver and brain, however, remain limited in their scope because they all suffer from the same flaw: they're too large and, therefore, too hard to deliver into cells, tissues or living organisms.

In a paper published Sept. 3 in Molecular Cell, Qi and his collaborators announce what they believe is a major step forward for CRISPR: An efficient, multi-purpose, mini CRISPR system. Whereas the commonly used CRISPR systems -- with names like Cas9 and Cas12a denoting various versions of CRISPR-associated (Cas) proteins -- are made of about 1000 to 1500 amino acids, their "CasMINI" has 529.

The researchers confirmed in experiments that CasMINI could delete, activate and edit genetic...

Leaky Sewers - Likely Responsible for Large Amounts of Medications in Streams

Many of the Monterey Bay cities have started addressing groundwater contamination. As a Monterey Real Estate broker, we have to get these inspections done as part of a sale in most cases. These inspections and repairs are often required as a condition of sale for single family homes and sometimes townhomes. Condominiums are often exempt for individual owners. If there's a leak or break in the pipes, those will need to be repaired, typically by the seller. The main sewer lines in question are between the home and the sewer main in the street. Oftentimes the yard has to be dug up, or if the connection at the main is faulty, the street. This can be expensive due to traffic mitigation and the depths sometimes of these connections. 

These leaking sewer pipe issues can be from the old clay or transite pipes that were used and having joint separations, to plastic lines that tree roots have invaded the couplings. Some plumbing companies pull in completely new single piece polyethylene that is then put in the line of the old faulty line. This "trenchless" style is the least disruptive of landscaping and walkways. A single line with no joints to separate or for trees to get their roots in is probably the best long term solution in my estimation. 

Typically these inspections are up to $350 to do with the camera, though some are free. That video file is sent to the appropriate jurisdiction and the public works personnel then directs what they think needs to be done to bring the pipe into compliance. It had been my belief the offending issues were more fecal matter contamination, but as you can see, quite a few drugs are causing potentially a much greater and more disruptive issue in the ecosystem. Fecal matter has always been a part of nature but these drugs have not.

The 2021 infrastructure bill may not...

Blocked Summertime Noises Using These Simple Techniques

I tried a variety of noise-cancelling devices, including white-noise makers, ear plugs, and noise-canceling headphones, but none of them seemed to work. 

BUILDING WORK

When dealing with extremely loud noises such as construction or road construction, you should start by lowering the decibels. When jackhammers and electrical saws cause your ears to become damaged, full, The Best White Noise Machineor ring, the noise is simply too loud and may be harming your hearing.

According to Sam Nicolino, the engineer who invented the white-noise devices LectroFan EVO and Sound+Sleep, the moderate rhythms of the white-noise machine should fill the room rather than sit in a nook.

READ MORE:

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Foreclosure: Right of First Refusal Following Trustee's Sale of One to Four Single Family Property

Foreclosure: Tenant's, prospective owner-occupants and non-profit's right of first refusal following trustee's sale of one to four single family property. No bundling of such properties at a trustee's sale.

First, this law grants tenants, prospective owner-occupants, nonprofit affordable housing providers, community land trusts, limited-equity housing cooperatives, and public entities a 45-day window to purchase residential property through foreclosure if they can match (in the case of tenants) or exceed (in the case of other purchasers) the last and highest bid made on residential one to four single-family homes at the foreclosure auction.  Second, this law prohibits sales of bundled properties at foreclusure auctions. Third, it increases local govenments' authority to assess fines on owners of blighted propeerties acquired at foreclosure sales.

C.A.R opposed this law as it creates a complicated and lengthy bidding and foreclosure sale process, causing uncertainty within the foreclosure transaction process.

This Law:

1) Forbids a foreclosure trustee from bundling properties for sale at a foreclosure auction, instead requiring that each property be bid on separately.

2) Provides an eligible bidder 45 days after a home foreclosure auction to make an offer for the home that exceeds the highest bid.  Defines "eligible bidder" to include: a) A tenant in the home, a prospective owner-occupant, or a nonprofit in which a propective owner-occupant or eligible tenant is a voting member or director. b) An eligible nonprofit based in California whose primary activity is developing and preserving affordable rental housing, a limited partnership for which an eligible nonprofit is the managing general partner; or a limited liability company in which eligible nonprofit corporation is the managing member. c) A community land trust or a limited-equity housing cooperative. d) The state, the University of California, a county, city, distruct,...

Community Water System Exemption - Senate Bill 974

Water: Community Water System Exemption

Senate Bill 974: California Environmental Quality Act: Small Disadvantaged Community Water System: Exemption - This measure will help impacted communities gain access to clean and safe drinking water.  This bill offers a modest but important exemption to very limited community water supply projects that will help certain residents obtain clean and reliable water. C.A.R. supported this measure as it will provide an exemption in CEQA to help expedite small community water projects.

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Ways to Make Aging-in-Place Upgrades that Won't Impact Home Value

It is not uncommon for homeowners to want to remain in their homes as they enter into their golden years. In some cases, this may require some home renovations or adjustments to make the home more easily accessible. But special renovations like these can make the home more difficult to sell should you ever decide you would like to because the home is full of items that would be useful to a small set of potential buyers.Ways to Make Aging-in-Place Upgrades that Won't Impact Home Value

There is a way that you can make your home ready for aging in place without taking away from its value or appeal of it. Here are some aging-in-place adjustments that can be made to a home that will help it to retain its value or may make it even more valuable and appealing.

Temporary Ramps and Railings

Sticking with temporary ramps and railings as opposed to permanently affixed ones is a much better and more cost-effective way to go. In the event of selling the home they can be easily removed. You can even rent one of these for a short period of time for less than the cost to purchase. Adding landscaping and shrubs to partially obscure the fixture will help to enhance aesthetics as well.

Choose to Utilize Only One Floor

Instead of installing an expensive stair lift to upper floors that will have to be removed by new homeowners that will not need it, consider putting the investment towards addition to the home that will increase its value or simply adjusting the way you use your home to use just one floor of the home for most of your daily needs.

Adding a first-floor master suite will allow you to have one-level living while adding a significant amount of value to the home as opposed to deterring some buyers...

Exemption from Reassessment Retained for Rebuilt Property Destroyed by Disaster up to 120% of Value of Original

In a Governor-declared disaster an exemption from reassessment will be retained for reconstructed improvements which are comparable to the improvement replaced if similar in size, utility, and function and within 120% of value of original property.

This law allows owners of property substantially damaged or destroyed in a Governor-declared disaster to reconstruct comparable improvements onsite with a return to the former improvement's base year value.  While existing law effectively allows this in a form of a new construction exclusion, this law adds a new provision specific to post-disaster reconstruction following a Governor-recognized event and allows a more generous comparability definition.  Specifically, it defines the term "comparable" using the same 120% definistion used when a victim of a major disaster decides to reconstruct replacement property on site of the damaged property.  Under this definition, reconstructed improvements will be found comparable to the improvement replaced if similar in size, utility, and function and withing 120% of value.  This law applies to real property damaged or destroyed by misfortune or calamity on or after January 1, 2017.

Assembly Bill 2013 is codified as Tax and Revenue Section 70.5. Effective January 1, 2021.

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Favorite Hotspots in Pacific Grove California

Ever wanted to escape your stressful life or wanted a getaway for your family? Then, Charming Pacific Grove is the place to go. This article features a few and must-visit hotspots in Pacific Grove, California, where you can have real fun if you happen to visit.

Asilomar State BeachFavorite Hotspots in Pacific Grove California

Asilomar State Beach is a beach with dunes, beautiful scenery, over 100 acres of forest, and stunning ocean landscapes. Its name is the beach, A Refuge by the Sea, as it is situated within the scenic and fantastic town of Pacific Grove. The beach offers comfy cottages and lodges for visitors. It also provides a beautiful view of sunset hence providing an unforgettable escape from the daily demands of life.

Wild Fish

Pacific Grove has more to offer than the scenery. Wild Fish, located a few blocks from Monterey Bay, offers natural 100% organic and imaginatively prepared seafood with an ever-changing menu sourced by the local farmers and fishers. The food is fresh, exactly what the locals want, making it an attractive neighborhood destination. So, reserve your space now and get the best from Wild Fish.

Monarch Butterfly Sanctuary

If you plan to visit Pacific Grove in October, Monarch Butterfly Sanctuary is a place to stop. In October, Butterflies cluster together on pines, cypress, and eucalyptus trees. It has been nicknamed "Butterfly Town," The community...

The Dangers of E-Cigarettes for Children

dangers of e-cigarretteWhile many behavioral trends are preventing children from maintaining good health these days, the introduction of e-cigarettes is certainly one of the most serious hazards to their physical and mental health. As noted in ScienceDaily, teenagers are increasingly using e-cigarettes. Public health experts are concerned about the trend, citing the devices potential role in promoting smoking as a major worry. Yet even if the e-cigarettes are not a gateway to smoking, they can still prove harmful to one's health. 

Why E-Cigarette Use Is On The Rise

There are several reasons why e-cigarette use is on the rise amongst children. One reason is ongoing exposure to advertisements. As noted by the CDC, roughly 69% of middle and high school students have been exposed to e-cigarette advertisements through mediums such as television, movies, magazines, newspapers, retail stores, and the internet. Additionally, some children may be attracted to the technologically advanced nature of the e-cigarettes. As battery-operated devices, e-cigarettes deliver nicotine along with other chemicals and flavorings in vapor rather than smoke. 

The Health Hazards Of E-Cigarettes

While many view the technological advancements of e-cigarettes as good insomuch as they expose users to less smoke, the health risks of the product are many. The hazardous nature of e-cigarettes has been cited by numerous officials and was published online through the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. The study indicates a correlation between use of e-cigarettes and persistent cough. Additionally, e-cigarettes...

Price Gouging: Increases the Scope of What Constitutes Price Gouging in the Sale of Goods or Services.

crime of price gougingThis law amends the crime of price gouging to 1) include where a person, contractor, business, or
other entity to charge a price that is more than 50% greater than either the amount the seller paid for the goods or the seller’s costs in selling or providing the goods or services; and 2) provide that the protections against price gouging may also apply to a timeframe prior to a date as set in the proclamation or declaration. It does not affect provisions of Penal Code 396 pertaining to the price of rental housing.

This law expands the crime for price gouging to also include selling or offering to sell those goods or services for a price 10% greater than the price charged immediately prior to a date set by the proclamation or declaration of emergency.  It makes it a crime for a person, contractor, busines, or other entity who did not charge a price for the goods or services immediately prior to the proclamation or declaration of emergency to charge a price that is more than 50% greater than the seller's existing costs, as specified.  It authorizes the Governor or the Legislature to extend the duration of these prohibitions for periods greater than 30 days, and during the extension, authorize specified price increases that exceed the otherwise permissible amount, as specified.

Senate Bill 1196 is codified as Penal Code 396.  Effective January 1, 2021.

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Breaking a leg...Finding a Better Way to Heal with the Scrail

Enduring multiple surgeries to set complex bone fractures with steel or titanium screws and plates may soon be a thing of the past. New bioceramic bone screws compatible with the body's own bone material and shaped to decrease injury to bones and tendons are being introduced by Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM.

backyard plants in monterey ca 

 The beginning of ski season is a hectic time for alpine emergency centers when injuries to the neck, knee, pelvis and hips (including hip fractures in mature skiers) are common occurrences. Those with complex bone fractures will undergo surgery to set then with titanium or steel screws and plates. But because these metal screws and plates can cause inflammation and allergies in sensitive people when left in the body, patients must endure considerable discomfort and expense having the metal pieces removed in a second operation after the injury has healed.

 Now a new bioceramic implant screw nail or "scrail", developed by researchers at Fraunhofer IFAM and the university hospitals of Giessen-Marburg and Bonn and the University of Bremen, is primed to turn such injury treatment into history. Walking on the beach is one of the things that is often good for therapy and general health here in in Monterey. Real estate that is close to the water of often sought out by those who have a frequent walking regimen to enhance mobility and flexibility.

The bioactive and...

Smart Ways to Save On Your Homeowner's Insurance

Some of us would consider the probability of not having homeowner's insurance, like paying for health and utilities. Such expenses are annoying, but we cannot avoid them. Despite this, have you ever wondered if you are paying too much for insurance? The problem with bills such as insurance is that we do not always think about saving after accepting them.Smart Ways to Save On Your Homeowner's Insurance

Homeowner's insurance policies vary due to a number of variables. Some of these variable influences how cheap or expensive an insurance policy is and identifying what to look for is essential. Luckily, it is not difficult to save on incentives by taking time to assess your current properties and the company's offerings. However, you should not sacrifice crucial coverage that could take a toll on you later to save a few coins in a short term. Here are some of the excellent tips that may help you save on homeowners insurance.

Related: Can you lower your homeowner's insurance?

Security

Consult your company on what you will do to cover your home from natural calamities and other risks. For example, you can save on your premiums by putting buying more robust materials, reinforcing the roof, or placing storm gutters. If you live in an old home, update your electric, plumbing, and heating systems to reduce fire and water accidents. In addition, you can get discounts for at least five percent if you install a burglar or fire alarm.

Identify what the company can cover and what it cannot

You should note that standard insurance policies do not cover damages...

This Home is 5 Minutes to Natural Bridges Beach and West Cliff Drive

This comfortable single level lower Westside Santa Cruz is just a 5 minutes to Natural Bridges Beach and West Cliff Drive. Hop on your bike and go wine tasting at the Swift Street wine district, after a day of surfing at Natural Bridges. As you enter the private courtyard, you'll notice this home is set up for enjoying the fine weather here by the coast. Lounge around the fire pit, sipping wine in the afternoon, or roasting marshmallows. The vaulted ceiling gives one these sense of being light and spacious as you enter the living room to start working on dinner in the remodeled kitchen. The master suite is spacious enough for a king sized bed, and has access to the outdoors and hot tub in the back yard. The other 2 bedrooms have a queen sized beds in them.The saltwater Jacuzzi tub, included, is heated to a pitch-perfect 101 degrees year-round, for a warming way to end the evening after a day of enjoying the events and activities that Santa Cruz has to offer. Call Gregg, 831-818-7524 for more information.

710_Modesto westside santa cruz home for sale

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